Giving bacteria the old one-two...three-four
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منابع مشابه
Giving Alzheimer's the Old One-Two
A dual goal for treating Alzheimer's disease (AD) is to decrease deposition of neurotoxic amyloid beta-peptide in the brain and to boost repair of damaged neurons. Donmez et al. (2010) now show that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid receptor beta, a potential new therapeutic target for AD.
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Cellular senescence, even in the presence of abundant nutrients, has now been demonstrated in several microbes, including most recently the bacterium Escherichia coli, suggesting that it may be a universal adaptive response to the inevitable damage to cell constituents that accumulates with time.
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Paul Bailey's first novel, 'At the Jerusalem', led to wide acclaim from the critics of a new writer of major importance. Dr. Ralph Emery, a psychiatrist, at Brookwood Hospital, Woking, who specialises in the problems of the elderly, reviews this story of This is not an entertaining book. It is not meant to be. Any pleasure in reading it is entirely derived from its literary merit and masterly u...
متن کاملFour viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet.
CD46 (also known as membrane cofactor protein or MCP) is a regulator of complement activation that is expressed in most or all human nucleated cell types. CD46 was initially identified as binding and inactivating C3b and C4b complement products, a process protecting human cells from lysis by autologous complement (18). It also serves as a receptor for several human pathogens: an enveloped RNA v...
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Pars planitis (PP) is an intermediate form of uveitis, which, if left untreated, can result in vision loss. Although phacoemulsification with IOL implantation in eyes with PP often results in improved vision, it represents a surgical challenge due to inflammatory sequelae and the possibility of postoperative complications. This case report describes a 4-year-old male who was admitted for poor v...
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ژورنال
عنوان ژورنال: Science
سال: 2014
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.345.6202.1307-b